In the process of writing my own research paper (Still WIP!) I got a few common target ranges together, I will go over them here and share my personal recommendations.
AuthPATH
AusPATH, the Australian guidelines recommend maintaining estradiol concerntrations above 250 pmol/L, in accordance with Cheung et al.
The Medical Journal of Australia
Ada S Cheung in DOI 10.5694/mja2.50259 recommend targeting estradiol levels of 250–600 pmol/L and total testosterone levels < 2 nmol/L
WPATH Standards of Care Version 8
The SOC8 state that serum testosterone levels should be less than 50 ng/dL and serum estradiol should be in the range of 100-200 pg/mL.
Journal of Clinical Endocrinology & Metabolism
Serum estradiol should not exceed the peak physiologic range: 100–200 pg/mL.
This graph is small excerpt from the research paper I am writing.
The target range I settled on for myself was for my E2 trough levels to sit around 650pmol/L. now I am specifically using Estradiol Undecylate so my peaks aren’t much higher than my lowest points (Estimated range of 680pmol/L peaks and 663pmol/L lows)1
I still feel a minimum of 650pmol/L is a useful value for most individuals, the usual dosages for EV(5 day cycle), EEn(7 day cycle), EC(7 day cycle) and EUn(28/30 day cycle) all keep you above that number anyway.
Footnotes
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These estimates are from estrannai, there is not enough data on EUn levels for this to be entirely accurate. you can reference the simulation here: https://estrannai.se/#i1_cu,32,28,5-32,28,5-32,28,5-32,28,5-32,28,5-32,28,5-32,28,5-32,28,5-32,28,5-32,28,5-32,28,5_c,32,28,5 ↩